This match has often been an exciting encounter between two teams that like to play attacking football. Newcastle's first major silverware in 70 years was won against Liverpool in the Carabao Cup final in March, with Alexander Isak scoring the winning goal.
However, Isak has been a subject of controversy after trying to force a move to Liverpool during the summer transfer window. As a result, he is not part of the matchday squad, and Newcastle will need to find alternative ways to score goals.
The Magpies have struggled to find the back of the net in their last three Premier League games, and their attack has been toothless at times. They have 47 shots and an xG of 5.57 in their last four games without Isak, but have only scored two goals in those matches.
Anthony Gordon was the most prolific player for Newcastle in their opening fixture against Aston Villa, taking seven shots but none of which found the net.
Goals have been a feature of this fixture in the past, with both teams scoring in 10 of the last 14 head-to-head matches. Liverpool have been a prolific scoring team under Arne Slot, netting 90 goals in his 39 Premier League games in charge.
Mo Salah has been a thorn in the side of Newcastle's manager, Eddie Howe, with 13 goals and eight assists in 14 Premier League appearances against either Bournemouth or Newcastle. He has at least one assist in each of his last six games against the Magpies.
Newcastle's recent record against Liverpool is not impressive, with the Reds winning five and drawing two of their last seven Premier League visits to St. James' Park. The Magpies have not beaten Liverpool in the English top-flight in the last 17 games.
Liverpool have won only one of their last four away league games, and Newcastle's manager, Eddie Howe, has won all three of his first home games of the season since joining the club.
Howe has issued a passionate plea to his players, urging them to use the energy from the crowd to deliver their game plan and not be reckless. Despite the odds being stacked against his side, he is confident that his team can put on a good display.
Now it's time for Newcastle to put their words into action and show the world what they are capable of. Can they handle the tension-packed test against Liverpool and get a positive result?